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Antineoplastic drugs, Immunosuppressants drugs, Corticosteroids drugs,…
Antineoplastic drugs
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Alkylation agents
Side effects
Hair loss
Missed periods
Reduced sperm counts
Damage to the mucosa lining in the intestines which may cause nausea.
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Indications
Treatment of autoimmune disorders systemic lupus erythematous and multiple sclerosis in patients with autoimmune hemolytic anemia.
Mechanism of action
Act by cross linking strands of DNA particularly at the N-7 position of guanine.
They are nonspecific for cell cycle phase and are thus active during most parts of the cell cycle
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Mitotic inhibitors
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Mechanism of action
Interfering with the ability of the cell division by blocking or altering the M phase of the cell cycle
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Immunosuppressants drugs
Immune modulators
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Mechanism of action
Kills myeloma cells
Inhibits the immune system modulation of cytokinesis production
Storage
2,25° degrees Celsius
Route
Orally
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Monoclonal antibodies
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Contraindications
Fluid overload
Pregnancy and lactation
Hypersensitivity due to repeat administration
Known allergy to drugs
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Mechanism of action
Attach to specific preceptor site to exhibit their immune suppressor action
Reacting as an antibody to human T cells
Disabling T cells and acts as an immune suppressor
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T and B cell suppressors
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Mechanism of action
Inhibition of cytokine production
Suppression of antibody production
Inhibits action of the cell mediate immunity
Corticosteroids drugs
Cortef
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Contraindications
Inactive tuberculosis
Herpes simplex infection of the eye
Pheochromocytoma
Insufficient of the hypothalamus and pituitary galnd
Mechanism of action
Hydrocortisone binds to the glucocorticoid receptor leading to downsiream effects such as inhibition of phosphokinase after Passage through the cell membrane corticosteroids react with receptor proteins in the cytoplasm to form a steroid receptor complex
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Ethamethasoneb
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Contraindication
An infection due to a fungus
A condition with low thyroid hormone levels
Intestinal infection caused by the roundworm strongyloides
Indication
Treatment of several inflammatory conditions
The corticosteroid is also available as injectable suspension and can be used to manage endocrine disorders
Mechanism of action
Binds to the specific intracellular glucocorticoid receptor and subsequently binds to DNA to modify gene expression
Storage
Last for seven days
Stored in a cool dry place
Route
IV, IMI, Subcutaneous
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