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corticosteroid drugs corticosteroids-589x305 - Coggle Diagram
corticosteroid drugs 
fludrocortisone acitate
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Trade names
Cortineff, Florinefe, and Fludrocortison
mechanism of action
Fludrocortisone bind the mineralocorticoids receptors(aldostero receptor). The binding or activation of mineral corticoids receptors by fludrocortisone in turn causes an ion and water transport and thus raises extracellular fluid volume and blood preasure and lowers potassium level.
indications
prophylactic management of asthma,Addison's disease, adrenogenetic syndrome, primary and secondary adrenocortical insuffieciency
Nursing considerations
Contraindications
Fludrocortisone must not be given to patients with fungal infection,thyroid disorder,renal impairment, active infection and those who are allergic to fludrocortisone acitate
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Hydrocortisone(IV)
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mechanism of action
therapeutic Hydrocortisone is a synthetic or semi-synthetic analog of natural hydrocortisone hormone produced by the adrenal gland with primary glucocorticoid and minor mineralocorticoids effect. As a glucocorticoid receptor agonist, hydrocortisone promotes protein catabolism, gluconeogenesis, capillary wall stability renal excretion of calcium and suppress immune and inflammatory response
indications
Relief inflammatory and pruritic manifestations of corticosteroidsresponsive ( adrenal insufficiency, Addison's disease
Nursing consideration
contraindications
Hydrocortisone must not be given to patient who is taking herbal medication and those who are allergic to it
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prednisone
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Mechanism of action
prednisone is a glucocortocoid receptor agonist. it is metabolized first in the liver it active form prednisolone . prednisolone crosses cell membrane and bind with high affinity to specific cytoplasmic receptor. This inhibit leukocyte infiltration at the site of inflammation an suppress humonal immune responses and reduction of oedema or scar tissue
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Nursing considerations
Monitor and report signs of peptic ulcer, including heartburn, nausea, vomiting blood, tarry stools, and loss of appetite.
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side effects
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nausea, stomach pain, bloating stomach
acne, increased sweating dry skin
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Methylprednisolone
mechanism of action
methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Unbound glucocorticoids cross cell membrane and bind with high affinity to specific cytoplasmic receptors, modifying transcription and protein synthesis. By this mechanism , glucocorticoids inhibit
leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, suppress humoral immune response.
Indication
Endocrine disorder for example congenital adrenal hyperplasia,hypercalcemia associated with cancer and nonsuppurative thyroiditis. Allergic state for example bronchial
asthma, contact dermatitis and seasonal or perennial allergic rhinitis
Nursing considerations
Contraindications
it must not be used to patient with fungal infection, ulcerative colitis, liver disease, multiple sclerosis
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