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Antidiabetic drugs : - Coggle Diagram
Antidiabetic drugs :
Metformin
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Mechanism of action
Metformin act via both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms; by inhibition of mitochondrial respiration but also perhaps by inhibition of mitochondrial glycerophosphate dehydrogenase, and a mechanism involving the lysosome.
metformin improves glycaemia by acting on the liver via AMPK activation, to a much more complex picture reflecting its multiple modes of action
Indications
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gestational diabetes, management of antipsychotic-induced weight gain,
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Nateglinde
Mechanism of action
Amino acid derivative that lowers blood glucose level by stimulating insulin secretion from the pancreas. Action dependent upon functioning better cells in the pancreatic islets. Interact with the ATP sensitive potassium ( K+ATP) channel on pancreatic beta cells
Indications
Nateglinide tablets are indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
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Pioglitazone
Mechanism of action
synthetic ligands for peroxisome proliferator-activated receptors (PPARs). They alter the transcription of genes influencing carbohydrate and lipid metabolism, resulting in changed amounts of protein synthesis and, therefore, metabolic changes.
Pioglitazone improves glycaemic control in people with Type 2 diabetes by improving insulin sensitivity through its action at PPAR gamma 1 and PPAR gamma 2, and affects lipid metabolism through action at PPAR alpha.
Indications
indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus in multiple clinical settings.
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