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Osteoarthritis, Elasticity and strength, Advanced age, Cartilage loss,…
Osteoarthritis
Etiology
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Initiation
- Mechanical agression/stimulation (hormones, medications, physical stress)
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- Immunological factors (accelerate and perpetuate)
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- Age
- Gender
- Race
<=> Influence time and pattern
Epidemiology
- 4% 18-24 yo
- 85% OA (70's)
- Men (45yo)
- Wowen (55yo)
- Heredity ---> OA DIP joint
- Obesity ---> Knee in women (excess fat metabolic effect on cartilage)
Risk factors
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Healthy people
Balance
- Synthetic enzymes
- Degratative enzyme
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Clinical manifestation
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Relieved by rest, worse with activity
Crepitation, limitation of range of motion Increased joint size and hardness but not swelling
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OA = DJD
- Most prevalent form of arthritis and is a leading cause of disability and pain in older adults
- Slowly progressive destruction of articular cartilage of weight-bearing joints (spine, hips, keens and feet) and fingers
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Joint injury
Inflammation
- Increase catabolism
- Decrease anabolism
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