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Pituitary drugs - Coggle Diagram
Pituitary drugs
octreotide
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indication
peptide drug used to treat acromegaly as well as diarrhea associated with metastatic carcinoid tumors and vasoactive intestinal peptide secreting tumors.
mechanism of action
binds to somatostatin receptors coupled to phospholipase C through G proteins and leads to smooth muscle contraction in the blood vessels. Downstream effects that stimulate phospholipase C, the production of 1, 4,5-inositol triphosphate, and action on the L-type calcium channels lead to the inhibition of growth hormone, treating the various growth-hormone and metabolic effects of acromegaly.9
corticotropin
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Mechanism of action
corticotropin combines with a specific receptor on the adrenal cell plasma membrane. it stimulates the initial reaction involved in the synthesis of adrenal steroids. from cholesterol by increasing the quantity of cholesterol within the mitochondria. Corticotropin does not significantly increase serum cortisol concentrations in patients with primary adrenocortical insufficiency.
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indication
For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency
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somatotropin
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side effect
tingling in your wrist, hand, or fingers
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mechanism of action
acts to mimic and restore the actions of endogenous growth hormone of stimulating linear bone growth, increasing bone mass, increasing muscle and reduced fat mass, and regulating blood glucose and lipid levels
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indication
is a recombinant human growth hormone used as replacement therapy in various conditions of growth failure, growth hormone deficiency, and weakness in children and adult
somatrem
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indication
recombinant growth hormone used to treat adult growth hormone deficiency and treat disrupted growth in children due to growth hormone insufficiency or deficiency
mechanism of action
binds to dimeric growth hormone (GH) receptors located within the cell membranes of target tissue cells resulting in intracellular signal transduction and a host of pharmacodynamic effects. Somatrem treatment also causes an increase in both the number and the size of skeletal muscle cells
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