Gigantism 
defination
pathophysiology
causes
signs and symptoms
occurs when the growth hormone hypersecretion occurs before the fusion of the long bone epiphysis and is characterized by a toe statue
it is secreted by the somatotroph cells in the anterior pituitary.
its circulates for the most part as a 22KD protein and the remaining as a 20KD protein
it is secreted in the pulsatile manner, 4 to 11 pulses in a day. due to this pulsatile nature of secretion measurement of random growth hormone levels are not useful.
growth hormone is a 191 amino acid protein with two disulfide bonds.
growth hormone releasing hormone stimulates the release of growth hormone from the pituitary. GHRH containing neurons are mainly seen in the arcuate nucleus and ventromedial nucleus.
somatostatin which is also secreted from the hypothalamus exert an inhibitory action on the secretion of GH
GHRH and somatostatin also regulate each others secretion in a paracrine manner
GH stimulate the synthesis of IGF-1 from the liver. IGF-1 is a seventy amino acid protein that is similar to insulin. beside post-receptor signaling mechanisms involving tyrosine kinase and insulin receptor substrate-1 (IRS-1) are also similar for IGF-1 and insulin
non cancerous pituitary tumors
multiple endocrine neoplasia type 1
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signs and symptoms
extremely tall stature
large hands and feet
prominant forehead and jaw
persistent headaches
goitre
impotence or poor libido
keep accurate assessment of height and weight
review medication regimens
educate family and patient
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expected outcome
encourage in involvement in extramural activities.
.offer emotional support to the patient.
.encourage patients socialization with environmental factors
.disturbed self perception related to growth of body parts as evidenced by amplified hands feet and jaw
patient to adapt to issues emerging from the presence of signs and symptoms
references
references
Gigantism ; Medline plus medical Enclopedia . Medlineplus.gov.retrived 2017-04-27
Gigantism and acromegaly ; practice , essential , background and pathophysiology . 2017-01-07
gigantism/UCLA pituitary tumor program. pituitary UCLA EDU retrieved 2017-04-27
diet therapy
eat breakfast and avoid snacking
soft , easy to chew diet
try to eat a portion of fish at least twice a week
choose low fat , low salt low sugar options
nursing diagnosis
nursing care plan
rationale
nursing intervention will help patient to gain confidence
will also help motivate client.
nursing interventions
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