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Evidence - Coggle Diagram
Evidence
CIViC
SYMBOL
ALK
BRAF
TP53
VARIANT_NAME
V600E
R1275Q
G12
BIOMARKER_DESCRIPTION
EVIDENCE_TYPE
Predictive
Prognostic
Diagnostic
EVIDENCE_LEVEL
A
B
C
D
E
DESCRIPTION
EVIDENCE_ID
EVIDNECE_DIRECTION
Does Not Support
Supports
NA
CLINICAL_SIGNIFICANCE
Resistance
Sensitivity/Response
Poor Outcome
...
VARIANT_ORIGIN
STATUS
CITATION
CANCER_TYPE
Thyroid Cancer
Solid Tumor
Acute Myeloid Leukemia
...
DISEASE_ONTOLOGY_ID
DRUG_INTERACTION_TYPE
Combination
Sequential
Substitutes
NA
RATING
0
1
2
3
4
5
THERAPEUTIC_CONTEXT
Vemurafenib, Cobimetinib
Trametinib
Midostaurin
MOLECULE_CHEMBL_ID
CKB
evidence
approvalStatus
#
Guideline
FDA approved
Phase II
Preclinical
Case Repots/Case Series
...
evidenceType
#
Actionable
Diagnostic
Emerging
Prognostic
efficacyEvidence
#
therapy
id
therapyName
#
Temsirolimus
Carboxyamidotriazole Orotate
Neratinib + Temsirolimus
synonyms
indication
id
name
#
breast cancer
squamous cell carcinoma
Advanced Solid Tumor
source
DOID
JAX
responseType
#
sensitive
resistant
decreased response
not applicable
...
ampCapAscoEvidenceLevel
#
A
B
C
D
NA
ampCapAscoInferredTier
I
II
NA
Id
#
fullName
PIK3CA exon9
BRAF V600
TP53 mutant
...
geneVariantDescriptions
description
#
gene
geneSymbol
#
BRAF
PIK3CA
TP53
...
variant
#
mutant
exon9
V600
...