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Metronidazole - Coggle Diagram
Metronidazole
Activity/Use
Originally used as an anti-protozoal agent
Anaerobic bacteria
Gram + bacteria
Gram - bacteria
Bacteroides
Septicemia
Bacteremia
Peritonitis
Brain abscess
Necrotizing pneumonia
Osteomyelitis
Pelvic abscess
Puerperal sepsis
Wound infection
Pelvic inflammatory disease
Fusobacteria
Acute ulcerative gingivitis
Clostridia
Pseudeomembranous colitis
Eubacteria
Anaerobic cocci
Gardnerella vaginalis
Bacterial vaginosis
H. pylori
Infection associated with peptic ulcers
Part of triple therapy
Trichomonas vaginalis
Urogenital trichomoniasis
Entamoeba histolytica
Amoebiasis
Gardia lamblia
Balantidium coli
Giardiasis
Acute dental infections
Side Effects
GIT
Diarrhea
Nausea
Vomiting
Skin
Urticaria
Rashes
Neurological
Dizziness
Headache
Pancytopenia
Disulfram (hangover)-like effect
Occurs with alochol
Alcohol inhibits aldehyde dehydrogenase
Mechanism of Action
Binds to DNA
Toxic oxygen products
Damages DNA
Prevents nucleic acid synthesis
Needs to be partially reduced to function properly
Only takes place in anaerobic organisms
Little activity in aerobic organisms
Bacteriodal
ADME
Administration
PO/IV
More often PO
Well absorbed and distributed
Excretion/Metabolisn
Excreted in urine
Slightly metabolised
Mainly unchanged
