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Rifampicin - Coggle Diagram
Rifampicin
Activity/Use
TB
Leprosy
Legionella
Eradication of...
N. meningitidis
H. influenzae
Serious
Staph. aureus
infections
Combination therapy
Gram + bacteria
Some gram - bacteria
Bactericidal
All mycobacteria
Side Effects
Hepatic impairment
GI upset
Colors body fluids orang
Increases rate of metabolism of other drugs
Mechanism of Action
Inhibits bacterial RNA polymerase
Can't bind to initiation sequence of DNA
No RNA synthesized
Bactericidal
ADME
Administration
PO/IV
Excretion/Metabolism
Liver metabolism
Interferes with CYP450
