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Polymixins - Coggle Diagram
Polymixins
Side Effects
Neurotoxicity
Dizziness
Ataxia
Confusion
Neuromuscular blockade
Nephrotoxicity
Acute tubular necrosis
Rash
Fever
GI disturbances
Mechanism of Action
Interacts with LPS in gram - bacteria
Displacement of Ca2+ and Mg2+
Derangement of cell membranes
Increased permeability of cell membrane
Leakage of cell contents
Cell death
ADME
Administration
Topical
IV
Nebulized
Highly protein bound
Need to monitor serum levels to avoid toxic levels
Activity/Use
Topical
Ear/eye infections caused by gram - bacteria
IV
For infections caused by resistant gram - bacteria
Carbapenemase producing
Enterobacterales
Resistant
Acinetobacter
Nebulized
Adjunctive treatment of gram - infections in CF
Examples
Polymixin B
Polymixin E/Colistin