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Monobactams (beta lactam antimicrobials): Aztreonam - Coggle Diagram
Monobactams (beta lactam antimicrobials):
Aztreonam
Mechanism of Action
Bactericidal
4-member core beta-lactam ring
binds to transpeptidatse (PBP) and prevent cross-link formation ---> inhibits cell wall synthesis ---> cell death
ADME
IV only
Only really used in the hospital setting
Excretion/Metabolism
Renal excretion
Dose reduction required in renal impairmemt
Side Effects
Rash
Pancytopenia
Suprainfections
C. difficile
infection
Convulsions
Activity/Use
Gram - bacilli
Pseudomonas aeruginosa
Pyelonephritis
Gram - respiratory tract infections (CF)
Intra-abdominal infections
In combination with other antimicrobials
Resistant to many beta-lactamase
Good for resistant gram - bacteria
