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Leukemias, M2-AML Acute myeloblastic leukemia with granulocyte…
Leukemias
Acute leukemia
Malignant neoplastic diseases that arise from the lymphoid or myeloid cell line
Etiology
Acute lymphoblastic leukemia (ALL)
Prior bone marrow damage due to alkylating chemotherapy or ionazing radiation
Adult T-cell leukemia/lymphoma > linked to infections with HTLV
Genetic or chromosomal factors
Down Syndrome
Acute myeloid leukemia (AML)
Pre-existing hematopoietic disorder > most common identifiable cause
Myelodysplastic syndromes
Aplastic anaemias
Myeloproliferative disorders
Environmental factors
Alkylating chemotherapy
Ionizing radiation
Benzene exposure
Tobacco
Classification
ALL
FAB
WHO
Immunophenotype: based on the origin (B cell or T cell)
AML
M2-AML Acute myeloblastic leukemia with granulocyte maturation
FAB classification for AML according to the histopathological appearance of the cells
M1-AML Acute myeloblastic leukemia with minimal granulocyte maturation
M0-AML Acute myeloblastic leukemia without maturation
M3-AML Acute promyelocytic leukemia (APL)
M4-AML Acute myelomonocytic leukemia
M5-AML Acute monocytic leukemia
M6-AML Acute erythroid leukemia
M7-AML Acute megakaryoblastic leukemia