Please enable JavaScript.
Coggle requires JavaScript to display documents.
Adrenergic drugs - Coggle Diagram
Adrenergic drugs
-
Indication
Alpha-1 receptor: Smooth muscle contraction, mydriasis
-
-
-
-
Side effects
-
-
Alpha-2 can cause hypotension, dry mouth and sedations
Beta-1 commonly cause tachycardia, arrhythmia, hypertension and anxiety
Beta-2 can cause tremors, tachycardia, palpitations and anxiety
Contraindications
Alpha-1 receptor agonists are relatively contraindicated in those who have the following medical conditions: hypertension, bradycardia, prostatic hyperplasia, and anyone using medications, which may also increase blood pressure.
Alpha-2 receptor agonists should be used cautiously in anyone who has low blood pressure. Geriatric patients may be at increased risk of falls due to the sedating and hypotensive effects.
-
-
-
Mechenism of action
Alpha1- receptor
Phospholipase C is activated, which leads to the formation of inositol triphosphate (IP3) and diacylglycerol (DAG). As a result, intracellular calcium rises.
Alpha2- receptor
Adenylate cyclase is inactivated, which leads to a decrease in intracellular cyclic adenosine monophosphate (cAMP).
Beta-1 receptor
Adenylate cyclase is activated, and intracellular cAMP increases.
Beta-2 receptor
The adenylate cycle becomes activated through the Gs-protein-coupled receptors, and there is an increase in intracellular cAMP. Gi protein-coupled receptors are also activated, and this will decrease intracellular cAMP.[11][12]
-
-