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A common challenge in older adults: Classification, overlap, and therapy
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A common challenge in older adults: Classification, overlap, and therapy
of depression and dementia
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Dementia
Underlying causes: Alzheimer's disease, vascular dementia, mixed dementia, Parkinsons, frontotemporal dementia
Depression
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Age-related diseases might damage frontostriatal circuitis, hippocampus and amygdala
Age-related psychosocial stressors: sosioeconomic status, disability and social isolation
Vegetative symptoms, attention and executive function deficits, psychomotor speed and working memory impairments are common
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Memory testing
AD --> low free recall rate, facilitation does not help
Depression --> attention problems, difficulties in encoding
The role of biomarkers
Three cerebrospinalfluid markers for AD --> total tau, phospho-tau, the 42 long amino acid long form of amyloid beta
Depression --> not clear markers but cytokines higher, tryptophan degradation (also interleukins and C reactive protein)
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