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Is it Beneficial to switch to fully synthetic heparin - Coggle Diagram
Is it Beneficial to switch to fully synthetic heparin
Ethics
Side effects from animal derived heparin
Cost and Availability of Synthetic Heparin
Contamination
In early 2008there was an increase in serious side effects associated with heparin Therapy, Thousands of patients were affected
These events included development of such symptoms as rash, fainting, racing heart, and other more severe symptoms.
The rapid onset of these symptoms suggests an anaphylactic response but the exact etiology is currently unknown.
Why synthetic vs Why animal derived
Synthetic
Synthetic would always have the same structure whereas animal based can have many variations such as
Some porcine intestinal heparin is prepared from porcine intestinal mucosa, scraped from the intestine, while other preparations use the whole intestine (“hashed pork guts”). These two raw materials contain differing amounts of structurally related heparan sulfate that can carry over into the final pharmaceutical product. There are also different subspecies of pigs, and the mast cell content of intestinal tissue can vary based on the diet and environment in which the animals are raised.
https://pubs.rsc.org/en/content/articlehtml/2009/np/b819896a
Animal
Cheaper to mass produce
5 Basic steps
1.Preparation of tissue (Porcine intestinal Heparin)
2.Extraction of heparin from tissue
Recovery of raw heparin
Purification of heparin
Recovery of purified heparin
https://pubs.rsc.org/en/content/articlehtml/2009/np/b819896a
History of animal derived from
Dog liver --> Beef lung --> Porcine intestine
