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Iron Metabolism - Coggle Diagram
Iron Metabolism
IRON ABSORPTION
Occurs in duodenum
Heme iron
Transported across enterocyte by HCP-1 (heme transporter)
Released from protoporphyrin in heme by heme oxygenase
Non-heme iron
Reduced to ferrous form by ferric-reductase
Enters enterocyte by DMT-1
Ferrous iron oxidized back to ferric iron by ferroxidase
incorporated into transferrin in the serum
BODY IRON DISTRIBUTION & TRANSPORT
Transferrin
Produced in liver
Transferrin receptor
Transporter glycoprotein dimer
Ferritin
Major iron storage
Water-soluble protein-iron complex
Primary storage form of soluble iron
Apoferritin → outer protein shell
Fe3+ → iron
NOT visible by light microscope
Hemosiderin
long-term storage form of iron
slow release
Insoluble protein-iron complex
Found in erythroblast and macrophage in BM
“Sideroblast”
hemosiderin-containing normoblasts
2 Forms of Dietary Iron
Heme iron (Fe2+, ferrous)
Non-heme (Fe3+, ferric)
REGULATION OF IRON METABOLISM
Controlled by 3 processes
Iron uptake
Iron utilization
Iron storage
Hepcidin
Produced by liver cells
Major hormonal regulator of iron homeostasis
Inhibits iron release from macrophage and iron absorption by intestinal epithelial cells
interacts w/ ferroportin (binding)