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barbiturate - Coggle Diagram
barbiturate
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pharmacokinetics
Barbiturates produce rapid (30-45 seconds) onset of unconsciousness following intravenous administration
Most barbiturates exist as a nonionized form and readily pass through the blood–brain barrier, leading to their fast onset of action.
major adverse reactions
Because of its relaxing effects on many of the body's organs, long-term barbiturate use can lead to breathing problems and pneumonia. Long-term use can also cause sexual dysfunction, delayed reflexes, a short attention span, and memory loss
pharmacologic effects
Barbiturates act by depressing the central nervous system, particularly on certain portions of the brain, though they tend to depress the functioning of all the body's tissues. Most of them exert a sedative effect in small doses and a hypnotic effect in larger doses
mechanism of action
The primary mechanism of action of barbiturates is inhibition of the central nervous system. It causes central nervous system depression. This is brought about by stimulating the inhibitory neurotransmitter system in the brain called the [gamma]-aminobutyric acid (GABA) system