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BASIC GENTICS :EXPERIMENTS, introduction, summary of the experiment -…
BASIC GENTICS :EXPERIMENTS
Griffith’s experiment
2 variants: non-virulent R-strain and virulent S-strain given to mice
Purpose
: To find the cure for pneumonia using bacteria
Conclusion being reached
R-strain = not deadly
Dead S-strain = not deadly
R-strain x Dead S-strain = deadly
R-strain "transformed" into live S-strain by acquiring dangerous component, aka "transforming principle"
Actually
, the transforming principle is DNA, however, this was unknown to Griffith. 20 years later, it was proven by Avery, McLoed and McCarty
Avery’s experiment
To break open dead cells, chemically separate the components and determine which was capable of transforming live S. pneumoniae cells
To test whether protein was the transforming factor, they treated Griffith's mixture of heat-treated deadly strain and live harmless strain with protein-destroying enzymes.
Avery concluded that DNA is the genetic material of the cell.
. Hersey- Chase’s experiment
In the mid-twentieth century, scientists were still unsure as to whether DNA or protein was the genetic material of the cell
It was known that some viruses consisted solely of DNA and a protein coat and could transfer their genetic material into hosts
:
introduction
summary of the experiment
