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EMBRYOLOGY GIS, STEROID, OVERVIEW GIS, Cranio-caudal Folding,…
EMBRYOLOGY GIS
WEEK 3
Gastrulasi
Ektoderm
Mesoderm
Endoderm
STEROID
Progesterone
Aldosterone
Estrogen
Androgen
Cortisol
OVERVIEW GIS
INGESTION
MOUTH
Oral Vestibule
Opening Parotid Gland
Oral Cavity Proper
Opening Sublingual & Submandibular Gland
Menghasilkan Saliva
Lubrikasi makanan
Enzim Amilase
Karbohidrat menjadi Oligosakarida
Tongue
Merasakan & Menelan makanan
Teeth
Menghaluskan makanan
Palatum
Hard
Membantu menghaluskan makanan
Soft
Mencegah makanan naik ke Hidung
BOLUS TERDORONG KE OROPHARYNX
Kontraksi
Aryepiglottic - Lateral Cricoarytenoid
Transverse Arytenoid - Oblique Arytenoid
Epiglottic menutup Larynx
PHARYNX
Oropharynx
Laryngopharynx
Relaksasi
Upper Esophageal Sphincter
BOLUS TERDORONG KE ESOPHAGUS
DIGESTION
ESOPHAGUS
STOMACH
ABSORBTION
EXCRETION
Cranio-caudal Folding
Fore Gut
OVERVIEW
Buccopharyngeal Membrace
Mouth
Pharyngeal Apparatus
Pharynx
Posterior Part
Esophagus
Stomach
1st & 2nd Duodenum
Liver
Gallbladder
Pancreas
Celiac Artery
Mid Gut
OVERVIEW
3rd & 4th Duodenum
Jejunum
Ileum
Cecum
Appendix
Ascending Colon
2/3 Proximal Transverse Colon
Superior Mesenteric Artery
Hind Gut
OVERVIEW
Cloacal Membrane
Anus
1/3 Distal Transverse Colon
Descending Colon
Inferior Mesenteric Artery
CORTICOSTEROID
Glucocorticoid
Mineralocorticoid
Lateral Folding
OBESITAS
EXCESS MACRONUTRIENT
Karbo
Protein
Lemak
Excess Lemak disimpan di Jaringan Non Adiposa
Excess Karbohidrat meningkatkan Lipogenesis
Excess Protein meningkatkan Gluconeogenesis
Lemak menumpuk banyak di Liver
LIPOTOXICITY
NEFA aktivasi NLRP3 di Kupffer Cells
Leptin Resistance
Leptin banyak di sirkulasi darah
Lapar terus menerus
Lemak disimpan di Jaringan Adiposa
Storage tidak cukup
Kupffer Cells produksi
IL-6
CCL2
Merekrut Monocytes
Merekrut Neutrofil
Neutrofil produksi
Elastase
Myeloperoxidase
Reactive Oxygen Species
Neutrophil Peptide 1
Inflamasi
Proliferation Stellate Cells
Apoptosis Hepatocyes
Cellular Stress Response di RE teraktivasi
Apoptosis Hepatocytes
Adipokines meningkat
Adiponectin menurun
Leptin
TNF a
IL-6
Adipocytes Hypertrophy & Hyperplasia
Hypoxia
Aktivasi Makrofag
Meningkatkan Uptake NEFA
Aktivasi Nuclear Factor Kappa B
Apoptosis Hepatocytes
Inflamasi
Hepatocytes produksi CRP
APPLE'S HEALTH APP
Height
Weight
BMI
Waist Circumference
Normal
Overweight / Obesitas
Normal
Lebar
BMI & WC Normal
"Isi Piringku"
BMI Normal & WC Lebar
BMI Overweight / Obesitas & WC Normal
BMI Overweight / Obesitas & WC Lebar
"Piring T"
Tips & Resep Diet Rendah Lemak
"Are you feeling tired today?"
Yes
No
Do you experience discomfort or pain in the Upper Right Side of your abdomen
Yes
No
EDUKASI & SARAN KE DOKTER
SARAN CEK GULA DARAH & KOLESTEROL
Jam & Lokasi CFD
Blood Cholesterol
Tips & Resep Diet Rendah Lemak
Reminder 1 bulan sekali
Reminder 1 bulan sekali
Reminder 3 bulan sekali
Kadar Kolesterol
Belum
Edukasi
Jam & Lokasi CFD
Ada
Normal
Tinggi
Tips & Resep Diet Rendah Lemak
5x dalam seminggu
IL-6 exercise gaada tnf alpha