Please enable JavaScript.
Coggle requires JavaScript to display documents.
morphine - Coggle Diagram
morphine
-
major adverse reactions
irregular, fast or slow, or shallow breathing
-
-
-
-
-
-
-
drug examples (names)
-
What is it? Non-synthetic narcotic (opioid) made from opium, prescribed as Kadian®,MS-Contin®, Oramorph SR®, MSIR®, RMS®, Roxanol
-
mechanism of action
Opiate drugs, such as morphine, interact with opioid receptors and produce analgesia by the same mechanisms as enkephalin, i.e., hyperpolarization of interneurons and depressing the release of transmitters associated with transmission of pain
Morphine binding to opioid receptors blocks transmission of nociceptive signals, signals pain-modulating neurons in the spinal cord, and inhibits primary afferent nociceptors to the dorsal horn sensory projection cells.1
pharmacokinetics
The pharmacokinetic properties of 3 (0.1 mg/kg, 0.2 mg/kg or 0.3 mg/kg) doses of oral morphine will be described. We will determine the dose of oral morphine that results in a peak plasma concentration that occurs within 60 - 90 min and results in the analgesic therapeutic range (10 - 40 ng/mL).