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CHRONIC INFLAMMATION AND WOUND HEALING - Coggle Diagram
CHRONIC INFLAMMATION AND WOUND HEALING
FUNCTIONS OF THE SKIN
protection
waterproof barrier
temperature regulation
immunity
sensory receptors
psychological
vitamin D synthesis
STRUCTURE OF THE SKIN
epidermis
superficial outer layer
melanocytes, langerhans cells, merkel cells
keratinocytes - main cell
cells become terminally differentiated as they move to surface
melanocytes in basal layer transfer pigment into keratinocytes
dermis
deeper true skin
fibroblasts, collagen, elastic and reticular fibres
dense irregular connective tissue
epithelial appendages
subcutaneous tissue
adipose tissue, macrophages
WHAT AFFECTS SKIN INTEGRITY
age
nutrition
circulation
environment
mobility
sensation
hydration
WHAT IS A WOUND
alteration in skin integrity
injury
disease
environmental assault
surgery
WOUND HEALING
highly regulated and synchronised process of cell
proliferation
differentiation
migration
angiogenesis
production of granulation tissue
co ordinated interaction and signalling
cells and ECM
PHASES OF CUTANEOUS WOUND HEALING
inflammatory phase
after injury
damage to blood vessels --> platelet aggregation and clot formation
recruitment of neutrophils and macrophages
proliferative phase
granulation tissue is formed
fibroblasts proliferate and secrete collagen
re epithelialisation over new granulation tissues
remodelling phase
occurs over weeks to months
granulation tissue is replaced by mature connective tissue scar
WOUND HEALING
acute wound
progresses through
hemostasis, inflammation, repair and remodelling
to replace
provisional wound matrix
with scar tissue
chronic wound
sequential healing is interrupted