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-RNA virus - Coggle Diagram

- - - - the characteristic symptoms of hydrophobia and certain death. negri bodies (intracytoplasmic)、唾腺釋出病毒
      - evidence of infection, including symptoms and the detection of antibody, does not occur until it is too late for intervention.
      - Postexposure prophylaxis is the only hope for preventing overt clinical illness in the affected person.
      - human rabies immunoglobulin (HRIG) or equine antirabies serum is recommended. + The rabies vaccine is a killed-virus vaccine prepared through the chemical inactivation of rabies infected tissue culture human diploid cells (HDCV)
  - - - 流行: Afica 為主、複製效率高、在Monocyte、Mphage、DCs等產生大量病毒、誘發 cytokine storm, 類似sepsis，嚴重內出血
  - - - A & B : 8 unique negative-sense RNA nucleocapsid segments、Hemagglutinin glycoprotein：the viral attachment protein and fusion protein; it elicits neutralizing, protective antibody responses.
        
        The antiviral drugs amantadine and rimantadine inhibit an uncoating step and target the M2 (membrane) protein for influenza A only.
        
        The antiviral drugs zanamivir and oseltamivir inhibit the neuraminidase protein of influenza A and B.
        
        The HA and NA of influenza A virus can undergo major (reassortment: shift) and minor (mutation: drift)
  - - - Arboviruses; Encephalitis、Hemorrhagic fevers;