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Diabetic Ketoacidosis :cheese_wedge: - Coggle Diagram
Diabetic Ketoacidosis :cheese_wedge:
Hallmarks:scroll:
Metabolic Acidos/Elevate AG
Hyperglycemia
Glucosuria
Ketonuria
Ketonemia
beta-hydroxybutyrate
acetone
Acteoacetate
DDX (ketogenesis)
Dehydration
Starvation
Insulin deficnecy
Diabetogenic Hormone Excess
*🧪
Min. QAT
PCV/TS = pH <7.35 = metabolic acidosis
Blood Gas
Electrolytes :zap:
hypo/normo/hyper-natremia 🧂
Hypo/normo -kalemia :banana:
UA
BUN/urea/Creatinine
Azotemia (hemoconcetration)
Dipstick
Ketonuria ( :green_cross: Beta-HB)
Glucosuria
Culture (2n UTIs)
Serum beta-hydroxybutyrate
:dog:
DKA: >3.5mmol/L:fire:
Diabetic: <2.8mmol/L
N: <0.15mmol/L
:cat:
Diabetic: 0.5-2mmol/L
DKA: >2.55mmol/L:fire:
N: <0.5mmol/L
BG = Hyperglycemia :baguette_bread:
Extend database
CBC
:arrow_up: PCV
Leukocytosis
Neutrophillia w/ left shift
Heinz Body :cat:
non regenerative anemia :dog:
Biochem
Hyperglycemia
:arrow_up: urea/creatinine
Mild :arrow_up:ALT/ALP/AST
:arrow_up: amylase & lipase
:hospital:
BG :arrow_down:
Regular insulin
IM
Initial: 0.2U/kg IM
Hourly: 0.1U/kg IM *until BG <14-17mmol/L
Once rehydrated switch to SQ
IM
Start at BG 14-17mmol/L -> Measure 2-4hrs
Dehydration: 0.1-0.4U/kg (4-6hr)
Hydrated: 0.1-0.5U/kg (6-8hr)
CRI
:one: Insulin:0.1IU/kg/hr + buretrol
:two: Dilute insulin in sml volume of 0.9%NaCl (select aprop riate ~10ml/hr)
:three: Purge IV line w/ 50ml of insulin:Nacl mixture
:four:Start solution on selected rate & monitor BG ~2hr
Dextrose once <14mmol/L
Goal: 11-14mmol/L
Electrolytes
🧂= will self correct w/ fluids
:banana:
Hypo = Urine loss + insulin
if <2.9mEq/L
CRI
0.5MeQ/Kg/hr (4hr max)
Mg
PO
Hypo = urine loss + insulin
tx
Dose range: KPO4 0.03-0.12mmol/kg/hr
0.1mmol/kg/hr IV for 6hrs
Rehydration :🌊(2hr before insulin)
Isotonic crystalloid :fire:
P148
PLA
LRS
Normosol
low 🧂
0.9% NaCl
Maintenance: 0.45% NaCl
Other considerations
Antiemetics
Metoclopramide
Ondansetron
Maropitant
Antibiotics (UTI)
Pain management
Feeding (NG/NE tube(
Clincal Signs 🤒
Polyphagia
Lethargy/weakness
Weight loss
Depression :frowning_face:
PU/PD
Hepatomegaly
Diarrhea
Vomiting
Muscle wasting
Acetone breath :beer:
Severe = Hyperglycemic Hyperosomlar Syndrome
Kussmaul breathing
Monitoring :eyes:
12hours
TPR
PCV/TS
Electrolytes
Blood gas
BG
Initialy: 2hr
2-6hr