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APPLIED RESEARCH: The process of molecule discovery - Coggle Diagram
APPLIED RESEARCH: The process of molecule discovery
from gene to function
Target Identification
from function to target
Target Validation
from target to hit
Hit Discovery
Traditional
Modern
from lead to candidate
Lead Optimization
Binding Interactions
Inter-protein
Protein-Ligand
Targets for drug discovery
Enzymes
Receptors
Molecular modelling
Molecular docking
Rational Drug Design
SBDD
Enzymes
Competitive/reversible inhibitors
: kinase inhibitors
Non competitive/irreversible inhibitors
: phosphatase PTP1B inhibitors
Allosteric inhibitors
: RNA polymerase NS5B inhibitors
LBDD
Receptors
Agonists
: CB2
Antagonists
: CB1