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Evaluation of NP adjuvancy, LbL technology, components - Coggle Diagram

- - - - R848 (Resiquimod)
- - - - Effect of saRNA Formulation on Protein Expression and Vaccine Immunology Dr. Anna Blakney
      - Enhansed saRNA delivery by pABOL (Blakney 2020)
        
        pAMAM
        
        PEI as a positive control
        
        ID & IM injections in mice of complexes with fLuc, after 7 days IP injections of XenoLight RediJect D-Luciferin
        
        Size of polymers (Blakney 2018)
        
        The physical properties of the delivery system, such as the available charge, charge density, and chain length, impact the complexation with DNA, mRNA, and RepRNA differently, which is likely due to variation in their physical properties.
        
        The optimal polymer for mRNA was found to be 80% hydrolysis, indicating that smaller RNA species may benefit from lower charge density. The smaller optimal molecular weight for mRNA, 45 kDa, also
        reflects the smaller size of mRNA