Genetics: Yes, heart disease can be hereditary, but it’s not as hereditary as people think, Dr. Matthews says: If you have relatives with heart problems in their 60s, 70s and 80s, their heart disease was probably acquired over time rather than running in the family. But if you have close relatives (parents, grandparents or siblings) who have had heart disease before age 50, then you may have a genetic predisposition, and it’s worth talking to your doctor about your risk.