Please enable JavaScript.
Coggle requires JavaScript to display documents.
Marine Invertebrate Natural products for Anti-Inflammatory and Chronic…
Marine Invertebrate Natural products for Anti-Inflammatory and Chronic Diseases
Arthritis and Osteoporosis
A condition involving inflammation of the joints and is a diseases affecting mostly the aged population
Marine invertebrates
Zoanthus sp.
Norzoanthamine could protect skeletal proteins in the host animal bodies from external stress
Enhance survival
Be a promising drug candidate for osteoporosis treatment and prevention
Neurodegenerative Disease
Progressive degeneration of structure and function of neurons.
Acanthella aurantianca
Hymenialdisine alkoloid
Inhibits phosphorylation of protein tau
Sinularia flexibilis
11-Dehydrosinulariolide
.
Promoting neuroprotective properties.
Corticium sp.
Stigmastane type steroidal alkaloid 4-acetoxy-plakinamine B
Inhibit acetylcholinesterase
Cardiovascular Disease
Marine invertebrates derived natural products have pharmacological
Marine invertebrates
sponge
Erylus formosus
Eryloside F to be a potent thrombin receptor antogonist
May stimulate endothelial cells to produce a vascular cell adhesion molecule
In further buildup of cells and shrinkage of the arterial diameter.
sponge
Halichondria okadai
Halichlorine act as an inhibitor for the expression of vascular cell adhesion molecule
May impede aetherogenesis
A class of disease that affects the heart, blood vessel, and blood circulation.
Diabetes
A most serious and chronic disease
Due to increasing level of obesity and aging of populations as well as unhealthy lifestyle
Marine invertebrates involve
Sponge:
Callyspongia truncata
Contains Callyspongynic acid which is a polyacetylenic acid that is isolated from the species
Inhibits 𝛼-Glucosidase
𝛼-Glucosidase inhibitors prevent glycogen from being hydrolyzed
Keeping the glucose concentration in
the blood at a lower level
Can be used to treat diabetic paients
Sponge:
Lamellodysidea herbacea
A polybromodiphenyl ether compound
isolated from an Indonesian marine sponge
inhibits protein tyrosine phosphatase 1B, an important target for diabetes treatment
Inflammation
Part of the complex biological response of vascular tissues to harmful stimuli
Such as pathogens, damaged cells or irritants
Signs of acute inflammation
Pain
Heat
Redness
Swelling
Loss of function
Different names of different parts
Body asthma: Inflammation o the airways
Arthritis: Inflammation of the joints
Dermatitis: Inflammation of the skin
Anti-inflammatory
Treatment that reduces infammations
Steroids
nonsteeroidal anti-inflammatory drugs (NSAIDS)
Herbal medicines
Marine invertebrates major groups of biological organisms
Porifera
Cnidaria
Mollusca
Arthropoda
Echinodermata
Invertebrates involve
Ascidian aplidium
- Inhibitors of human neutrophils
Soft coral
Lobophytum crissum
- Inhibitors of iNOS and COX-2
Soft coral
Lobophytum duru
- inhibitors of both iNOS and COX-2
Junceella fragilis
(Taiwanese gorgonian) -Inhibitors of human neutrophils
Brazilian sponge:
P. angulospiculatus
– Inhibitors of thromboxane B2 release from activated rate brain microglia
New Zealand ascidian
Synoicum sp.
– Inhibitors of human neutrophils
Marine sponge
Stylissa carteri
– inhibitors of neutrophil chemotaxis
Cancer
Marine Invertebrates & Chemical Found + Function
Phylum Porifera
Zyzzya fuliginosa
Makaluvamine A
: Inhibition of Colon cancer (IICT-116)cells
Spirastrella spinispirulifera & Hyrtios erecta
Spongistatin
: Inhibits apoptosis in Jurkat cells
Hyrtios
sp.
Heteronemin
: Inhibits NF-kB activation and activate caspase-8 & caspase-9 for inhibition of Leukemia (K562 cell) cancer cells
Cymbastela
sp.,
Hemiasterella minor
,
Siphonochalina
sp. &
Auletta
sp.
Hemiasterlin
: Potent inhibitor of cell growth, depolymerizes microtubles & arrests cells in G2-M phase of cell cycle.
Halichondria okadai & Axinella
family
Eribulin mesylate
: Microtubule dynamics inhibitor & currently in phase 1 clinical studies.
Phylum Mollusca
Elysia rufescens
Kahalalide F
: Inhibit topoisomerase II in cancer
Dicathais orbita
Tyrindoleninone & 6-bromoisatin
: Induces apoptosis in ovary, granulosa & choriocarcinoma (OVCAR-3, KGN, Jar) cells.
Genus
Lamellaria
Lamellarin D
: Stabilizes topoisomerase I DNA complexes and inhibits leukemia cancer cells.
Phylum Chordata Subphylum Tunicata
Cystodytes dellechiajei
Ascididemin
: Inhibits Leukemia (HL-60 & P388) cancer cells
Aplidium albicans
Aplidin
: Currently in phase 2/3 clinical trials for solid & hematologic malignancies.
Ecteinascidia turbinate
Trabectidin
: Anticancer effect in breast & prostate. Combination with pegylated liposomal doxorubicin for patient with relapsed platinum sensitive ovarian cancer.
Phylum Arthropoda
Various species of crabs & shrimps
Chitosan
: Inhibits and induces apoptosis of HeLa cancer cells
Phylum Bryozoa
Bugula neritina
:
Bryostatins
: Induces apoptosis in HL-60 chronic lymphocytic leukemia & combinations with other anti-cancer drugs. Currently under investigation.
HIV/AIDS
Human Immunodeficiency Virus affect the function of immune system.
Inhibitions of HIV-1 infection
Ascidians
Didemnum guttatum
Cyclodidemniserinol trisulphate
Inhiits HIV-1 integrase
Didemnid ascidians
Lamellarins
Inhibits the integrase terminal cleavage activity and strands transfer activity
DIdemnum sp.
Didemnaketals A and B
Inhibits HIV-1 protease
Horseshoe crabs
Limulus polyphemus
Tachyplesins I-III, polyphemusins I and II
HIV cell fusion inhibitors
Tachypleus tridentatus
Poriferans
Monanchora sp.
polycyclic guanidine alkaloid, crambescidin 8266
Inhiits HIV-1 envelopemendiated fusion
Madagascan lendenfeldia
C22 furanoterpene (dehydrofurodendin)
Inhibits HIV-1 RT-associated RNA and DNA directed DNA polymerase
Sidonops microspina
cyclic depsipeptide microspinosamide
Inhibits HIV-1 infection on cell-based
Neamphius huxleyi
Neamphamide A
Inhibits cytopathic effect of HIV-1 infection in cell-based
Clathria sp
.
Clathsterol
Inhibits HIV-1
Petrosia similes
Petrosin, petrosin A
Inhibits HIV-1 replications, formation of giant cells, and recombinant reverse transcriptase