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Malignant neoplasms - Coggle Diagram

- - - - Cytokine identical to TNF:
        
        Anorexia
        
        Fever
- - - - histological characteristics
    - - Size and spread
- - - - Tumor suppressor: p53
        
        p53 genes mutation implicated in lung, breast, colon cancer
        
        Initiates apoptosis of tumors cells (chemotherapy)
        
        If inactivated = uncontrolled growth
    - - Regulating the growth and proliferation of normal cells
        
        Produce:
        
        Growth factors
        
        Growth factor R
        
        Second messager
        
        Somatic mutations transform these proto-oncogenes into oncogenes