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Macronutrients: Lipids - Coggle Diagram
Macronutrients: Lipids
Diet-heart hypothesis
The seemingly simple diet-heart hypothesis was first proposed by nutritionist Ancel Keys in the early 1950s
The hypothesis outlined a sequence of relationships in which a fatty diet elevates serum cholesterol levels, leading to atherosclerosis and myocardial infarction
The seemingly simple diet-heart hypothesis was first proposed by nutritionist Ancel Keys in the early 1950s
Ancel Keys work interestingly claimed that saturated fat consumption cause heart disease not directly, but by raising cholesterol
Atherosclerosis
Atherosclerosis is the buildup of fats, cholesterol and other substances in and on your artery walls
Cholesterol biosynthesis
About 20% of total daily cholesterol production occurs in the liver; other sites of higher synthesis rates include the intestines, adrenal glands, and reproductive organs
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Lipoproteins
For transport in plasma
Lipids & cholesterol complex with carrier proteins (apolipoproteins) to produce soluble lipoproteins
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Different sized lipoproteins: Chylomicrons, VLDL, LDL, IDL, HDL
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Fat as a macromolecule
One of the 4 macromolecules of life (Nucleic Acids, Protein, Lipid, Carbohydrate)
Unlike the others, the have a wide variety of structures
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Fat in the diet
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“High carbohydrate intake was associated with higher risk of total mortality, whereas total fat and individual types of fat were related to lower total mortality.”
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Ketogenic diet
The ketogenic diet is a high-fat, adequate-protein, low-carbohydrate diet that in medicine is used mainly to treat hard-to-control epilepsy in children
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