In Act 4, Scene 1 the witches persuade Macbeth through apparitions, that Macduff poses no threat as fate will ensure his demise, line 85, “Be bloody, bold and resolute; laugh to scorn the power of man for none of woman born shall harm Macbeth”, On foot of this , Macbeth impulsively decides to murder Macduff’s family. Line 158/159: “His wife, his babes, and all unfortunate souls That trace him in his line,