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Pain and inflammation - Coggle Diagram
Pain and inflammation
Inflammatory Mediators
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ATP, Acetylcholine, Serotonin (5HT) & Prostaglandins released from damaged endothelial cells & platelets
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Histamine released from mast cells in response to Substance P released by primary afferent sensory fibres
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Definition of Pain
" An unpleasant sensory and emotional experience associated with actual or potential tissue damage , or described in terms of such damage"
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Inflammatory Mediators
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Not preformed, generated in damaged cells from phospholipids in the cell membrane.
Vascular mediators like Complement C5a on neutrophils, Bradykinin on fibroblasts act on these cells and break down the phospholipid in the cell membranes into arachidonic acid which is converted into Eicosanoids.
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Pain Sensation
Pain is mediated by chemical algogens that are mediators released from tissues that activate specific pain receptors - "nociceptors"
Activation of nociceptic pathways in the peripheral and central nervous system leads to psycho behavioural & sensory experience
Inflammation
Acute Inflammatory reaction is a normal defensive reaction to insult , injury or infection.
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