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Drug about pituitary hormone - Coggle Diagram
Drug about pituitary hormone
Growth hormone
Agonist
Mecasermin
MOA: recombinant form of IGF-1 --> stimulate IGF-1 receptor
Side effect: hypoglycemia, intracranial (顱內) hypertension
Somatostatin
MOA: Somatotropin release-inhibiting factor, SRIF
--> inhibit release of GH, TSH, glucagon, insulin, gastrin
Side effect: nausea, skin rush, stomach upset
Indication: GI hemorrhage (出血)
Somatropin
MOA: recombinant form of GH --> stimulate the secretion if IGF-1
Side effect: gynecomastia, nevus (痣) (但兒童多適應良好)
Turner syndrome --> 中耳炎
Octreotide
SRIF analogue
45X inhibiition of growth hormone, 30X longer half-life
Antagonist
Pegvisomant
Indication: acromegaly 肢端肥大症
Gonadotropin
Follicle stimulating hormone (FSH)
Follitropin alpha & beta
recombinant FSH
shorter half-life than purified human FSH
Urofollitropin
purified human FSH
Indication
卵巢刺激、男性hypogonadism造成的不孕
Side effect
卵巢過度刺激、多胞胎、男性女乳、憂鬱、頭痛、水腫
Human chorionic gonadotropin (hCG)
Choriogonadotropin alpha
recombinant hCG
MOA: mimic effect of LH
Indication: 促使卵子成熟、控制排卵、男性hypogonadism
Side effect: 卵巢過度刺激、 憂鬱、頭痛、水腫
Gonadotropin releasing hormone (GnRH)
Analog
Indication: 控制排卵、前列腺癌...
Drugs: Gonado
relin
, Buse
relin
, Histe
relin
, Leuprolide, Nafa
relin
, Tripto
relin
Side effect: menopause (continuous treatment), headache (Gonadotropin)
Pulsatile secresion --> stimulate the release of FSH, LH
Sustained secresion --> inhibit the release of FSH, LH
Antagonist
MOA: competitive antagonism of GnRH receptor
Indication:
supression of gonadotropin production (1)
reduce conc. of gonadotropin and androgen for prostate cancer (2)
Side effect: androgen deprivation
Drug: Gani
relix
, cetro
relix
(1), Abra
relix
, Dega
relix
(2)
Prolactin
Dopamine (D2) agonist
Bromocripton, Cabergoline
Indication: acromegaly, hyperprolactinemia, Parkinson's disease
Side effect: nausae, dizziness, chest pain, seisure
Quinagoline
Indication: hyperprolactinemia
Pergolide
withdrawed from market because of an increase risk of heart valve damage
Oxytocin
Atosiban
MOA: block oxytocin receptor and decrease uterine contraction
Side effect: increase th risk of infant death
Indication: 安胎
Vesopressin (ADH)
Analog
Desmopressin (DDAVP)
MOA: act as ADH but have 4000X antidiuretic activity
Indication: diabetes insipidus 尿崩症, pediatric noctunal enuresis 兒童夜尿症, hemophillia A, von Willebrand disease
Side effect: GI, headache, hyponatremia, allergic reaction
nona-peptide, synthetic vasopressin
Antagonist
Conivaptan, Tolvaptan
MOA: reduce water reabsorption without sodium loss
Indication: hyponatremia
Side effect: infusion site reaction