Please enable JavaScript.
Coggle requires JavaScript to display documents.
Antidiabetic drug - Coggle Diagram
Antidiabetic drug
SGLT2 inhibitor
-
Side effect: glycosuria, 利尿, ketoacidosis
Drug: Canagliflozin, Dapagliflozin, Empaglifiolin
-
Secretagogue
Sulfonylurea
Drug:
1st gen: Tolbutamide, Tolazamide, Chlorpropamide
2nd gen: Glyburide, Glipizide, Glimepiride
-
-
Side effect: Hypoglycemia, weight gain, hepatic & renal
meglitinide
-
-
Side effect: Hypoglycemia, weight gain, hepatic & renal
Insulin sensitizer
Biguanide
MOA: increase glucose uptake, decrease gluconeogenesis
Indication: type 2 DM, POCS(多囊性卵巢症候群)
Side effect: GI discomfort, Vit B12 insufficient, lactic acidosis
-
Thiazolidinedione
MOA: stimulate PPAR gamma --> increase GLUT1, GLUT4 expression
-
Drug: Pioglitazone, Rosiglitazone
-
-
Incretin-based therapy
GLP-1 analog
-
Drug: Exenatide, Liraglutide, Albiglutide, Dulaglutide
-
DPP-4 inhibitor
-
-
Drug: Sitagliptin, Saxagliptin (active metabolite)
-