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NSAIDs, Golt treatment, Acetaminophen, DMARDs - Coggle Diagram
NSAIDs
nonselective COX inhibitors
Drugs
Acetiic acid
Diclofenac
high selective
Ketorolac
Indomethacin
Propionic acid
Ibuprofen
Naproxen
Ketoprofen
Fenamic acid
Enolic acid
Meloxicam
high selective
long half-life
Piroxicam
long half-life
Salicylic acid
Aspirin
irreversible
inhibition of COX (acetylation of COX)
Specific side effect: salicylism (聽力損傷), hyperpnea (alkalosis)
不可用於兒童: Reye's syndrome
indication
anti-inflammatory
analgestic
anti-pyretic
gult (痛風) (exception: Aspirin, Tolmetin)
prevent heart disease
prevent colon cancer
treat Alzheimer's disease
patent ductus arteriosus (PDA) (開放性動脈導管)
Side effect
胃潰瘍
抗凝血
氣管收縮
高血壓
Selelctive COX-2 inhibitors
Coxib
Celecoxib
analgestic, antipyretic, anti-inflammatory
no effect on platelet aggregation
higher cardiovescular thrombotic event
Rofecoxib
Valdecoxib
Golt treatment
Allopurinol, Febuxostat
competitive inhibitor of xanthine oxidase
Hypersensitive (HLA-B5081 gene)
Colchicine
減少尿酸生成
Probenecid, Sulfinpyrazone, Benzbromarone
促進尿酸排除
Acetaminophen
no significant anti-inflammatory / platelet-inhibition properties
Aspirin的極佳替代品(過敏、兒童...)
DMARDs
slow acting
slow the disease progress