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Pernicious Anemia, References - Coggle Diagram

- - - - Activation of gastric dendritic cells
        
        Trigger CD4+ T cell lymphocytes in perigastric lymph nodes
        
        CD4+ T cells identify and damage the proton pump ATPase
    - - Type 1 work against the cobalamin (vitamin B12) binding site
        
        Intrinsic factor (IF) loss
        
        Lack of IF to bind vitamin B12
        
        Lack of B12-IF complex to bind to cell surface receptors in the ileum
        
        Defective absorption of vitamin B12
        
        Lack vitamin B12 to synthesize the enzyme methionine synthase
        
        1 more item...
        
        Lack of vitamin B12 to synthesize the enzyme methylmalonyl-CoA mutase
        
        1 more item...
      - Type 2 work against the ileal mucosa receptor
- - - - The destruction of gastric parietal cells
        
        Lack of the glycoprotein intrinsic factor
- - - - Hemoglobin concentration <13 g/dL for men and <12 g/dL for women
      - The mean corpuscular volume (MCV) greater than or equal to 100 fL
- - - - Monthly injections