ENDROCRINE SYSTEM
About Endocrine System
The endocrine system is a network of glands in your body that make the hormones that help cells talk to each other. They’re responsible for almost every cell, organ, and function in your body.
Properties of Endocrine System
Transmission (Spreading) of signals is slow
Hormones travel long distances via bloodstream
Only target cells respond to the signals
The effects of hormonal system tend to last longer
Chemical signals bind to receptor proteins on target cells
Both animals and plants have this system
Endocrine system is slower than nervous system because it takes time for a specific hormone to reach its target tissue via bloodstream
PITUARITY GLAND
Posterior Pituarity Hormones
Anterior Pituarity Hormones
Tropic Hormones
Nontropic Hormones
ADRENAL GLAND
Prolactin (PRL)
Melanocyte-stimulating hormones (MSH)
Growth Hormone
Functions
Melanocyte-stimulating hormone (MSH), influences skin pigmentation in some vertebrates and fat metabolism in mammals
Functions
Functions
Growth hormone has tropic and nontropic actions.It is made up of 200 amino acids. It promotes growth directly and has diverde metabolic effects.
Prolactin; stimulates lacation, growth of mammary glands and production of milk. It also plays a role in carbohydrates and fat metabolism
Follicle-stimulating hormone (FSH)
Functions
FSH stimulates follicle growth and estrogen hormone production during menstrual cycle in females
Thyroid-stimulating hormone (TSH)
Functions
TSH controls secretion of hormones fromthyroid gland. Excess TSH stimulate thyroid glands more, and more hormone produced in thyroid glands which eventually cause increase in thyroid gland cells and thyroid glan enlargement
Adrenocorticotropic hormone (ACTH)
Functions
ACTH controls secretion os steroid hormones from cortex region of adrenal glands
Luteinizing hormone (LH)
Functions
LH stimulates ovulation and corpus luteum formation. LH controls production of estrogen and progesterone hormones from corpus luteum in females
excess of GH
Acromegaly
Gigantism
lack of GH
Dwarfism
Oxytocin
Functions
Oxytocin includes uterine contractions and the release of milk.
How it works
Suckling sends a message to the hypothalamus via the nervous system to release oxytocin, which further stimulates the milk glands
Antidiuretic Hormone or Vazopressin (ADH)
Functions
Balance osmotic pressure of blood
Secretion of ADH is controlled by a negative feedback mechanism
THYROID GLAND
Release
Thyroxine
Calcitonin
Functions
Thyroxine hormone stimulate metabolism and influence development and maturation.
Increase aerobic respiration, therefore oxygen consumption and energy production
Increase protein synthesis during growth and development
Increase blood pressure and heart beat rate and metabolic rate
Malfunctions
Hypothyroidism
caused by
Low secretion of thyroid hormones
causes
Weight gain, lethargy and intolerance to cold
Goiter
Cretinism
Hyperthyroidism
causes
caused by
Thyroid gland becomes enlarged
Iodine deficiency or tumors
causes
caused by
Thyroxin deficiency during childhood
Characterized by impairment of mental and physical growth
caused by
causes
High body temperature, weight loss, irrtability and high blood pressure
Excessive secretion of thyroid hormones
Grave`s Disease (Toxic Goiter)
causes
caused by
Characterized by weight loss, irritability, muscle weakness, sleeping problems.
Is a form of hyperthyroidism in humans
It stimulates Ca²⁺ desposition in bones and decreases reasorbtion Ca²⁺ in kidneys and increases excretion of Ca²⁺ by urine
Works antagonistacally with parathyroid hormone to balance calcium (Ca²⁺) in the blood of mammals
Calcitonin decreases the Ca²⁺ level blood
PARATHYROID GLAND
Release
Parathyroid hormone (PTH)
Functions
Malfunctions
Parathyroid hormone regulates calcium levels in the blood, largely by increasing the levels when they are too low.
It does this through its actions on the kidneys, bones and intestine
Deficiency (Tetany)
Low Ca²⁺ level increase excitability of nerve without rest and results in continuous muscle contraction
It causes painful muscle contraction
If larynx muscles affected by this condition, results in death
Excess
Bones become weak and brittle (easily broken). Precipitation of Ca²⁺ with PO³⁻ in kidneys cause kidney stone
Adrenal Medulla (inner) hormones
Adrenal cortex (outer) hormones
GONADAL SEX HORMONES
About
The Adrenal medulla secretes epinephrine (adrenaline) and norepinephrine (noradrenaline)
These hormones are members of a class of compounds called catecholamines
They are secreted in response to stress-activated impulses from the nervous system
They mediate various fight-or-flight responses
Effects of epinephrine and norepinephrine
Increased blood pressure
Increased metabolic rate
Increased breathing rate
Change in blood flow patterns, leading to increased alertness and decreased digestive, excretory and reproductive system activity
Glycogen broken down to glucose; increased blood glucose
Increase oxygen delivery to body cells
Trigger the release of glucose and fatty acids into the blood
The Adrenal cortex releases a family of steroids called corticosteroids in response to stress
These hormones are triggered by a hormone cascade pathway via the hypothalamus and anterior pituarity
ACTH released from anterior pituarity control the adrenal cortex hormones secretion
Types of corticosteroids
Mineralocorticoids
Androgens
Glucocorticoids
Cortisone
Cortisol
It stimulates the production of glucose from fats and aminoacids
High levels of cortisol results in Cushing Syndrome
Cortisol, influence glucose metabolism and the immune system
It suppresses the immune system, thus reducing inflammation and attendant pain and swelling at the site of the injury
Long-term use of cortisone may trigger infections
Cortisone, whish is much like cortisol, sometimes is used to treat arthrities
Acts on the tubules of the kidney to stimulate reabsortion of sodium and water into the blood and excrete potassium
Low levels of aldosterone results in Addison disease characterized by low blood pressure, bronzing of skin and open to infections
Aldosterone, affect salt and water balance in blood
The Adrenal cortex also produces small amounts of steroid sex hormones; estrogen, progesteron and testosteron. Women may have masculinization from oversecretion of adrenal male sex hormone
Testes hormones
Ovarian hormones
Sex hormones
Progesteron
Androgens
Estrogen
Stimulates development of male secondary sex characteristics; large vocal cords, pubic hair, etc.
Largely responsible for the sex drive and probably aggressivness
Stimulates development and maintenance of the male reproductive system
Secreted at puberty stimulate maturation of ovaries and other sexual organs
Necessary for oocyt (egg) development
Estrogen is released from follicle and responsible for maintenance of the female reproductive system
Responsible for development of female secondary sex characteristics; a layer of beneath skin, larger pelvic girdle, etc
PANCREAS
Insulin (secrete from beta cells)
About
It is a mixed type of gland that shows both endocrine and exocrine functions. It is located between stomach an duodenum
Acinar Cells secrete and release pancreatic juice into the virsung duct that ends with duodenuö. %98 of pancreas is made of Acinar cells that function as exocrine glands
Islets of Langerhans have two kinds of cells. Alpha cells secrete glucagon and Beta cells secrete insulin. Both hormones are given to the blood directly. Therefore, they function as endocrine glands
Decrease blood glucose level
Increase the permeablility of cells to take glucose except brain cells
Stimulate conversion of glucose to glycogen as storage form in liver and muscles
Glucagon (secrete from alpha cells)
Increase the glucose metabolism in cells (conservation of glucose to glycogen or lipids)
Works antagonistacally with glucagon to adjust blood glucose level
Increase blood glucose level
Stimulates passage of glucose from cells (especially liver cells) into blood
Stimulate fat breakdown
Functions in conservation of glycogen to glucose into liver
Increases absorption of glucose in the ileum
Works antagonistacally with insulin to adjust blood glucose level
TYHMUS GLAND
Thymus is the primary lymphoid organ of the immune system. It secretes thymic hormone.
It is needed for development of T-lymphocytes.Thymus is largest and most active during the neonatal and pre-adolescent periods.
By the early teens, the thymus begins to atrophy and thymic stroma is mostly replaced by adipose (fat)
PINEAL GLAND
Melatonin
Serotonin
The pineal gland, located in the brain, secretes melatonin, primarily at night. Light /dark cycles control release of melatonin. Primary functions of melatonin appear to relate to biological rhythms associated with reproduction
Melatonin may cause seasonal affective disorder where persons are depressed at onset of winter
It is a contributor to feelings of well-being and happiness. It increases sexual desire.The activity of serotonergic neurons is slowest or absent during sleep and highest during states of alert wakefulness
Serotonin may also be important in the neural pathways controlling mood