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Cell Cycle - Coggle Diagram
Cell Cycle
Checkpoints
Between G1 and S phase
Between G2 and mitosis
During metaphase
Proteins that regulate checkpoints
Cyclin Dependent Kinases
Adds phosphate group to activate or inactivate a molecule
Always present but inactive
Inhibited by tumor supressor p53
Cyclin
Activates CDKs
Made at certain times
G1
Cyclin D (CDK4 and CDK6)
Partially phosphorylates Rb which prevents DNA synthesis blocking
Rb is bound to E2F (transcription factor) which activates transcription of Cyclin E
Cyclin E (CDK2)
Fully phosphorylates Rb
Phosphorylates p27 kip1 (inhibitor of Cyclin D)
S
Cyclin A (CDK2)
Activates DNA replication
G2
Cyclin B (CDK1)
Activates mitosis