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46-year-old man - Coggle Diagram
46-year-old man
Risk factors
Antecedent infection
Campylobacter jejuni
infection
Respiratory infections
Flu-like symptoms
Nausea
Fever
Gastrointestinal infection
Watery diarrhea
B-cells create antibodies on the antigens of the
C. jejuni
Molecular Mimicry
Production of ganglioside antibody:
Anti-GD1a, GM1, GQ1b
Binds to peripheral nerve membranes, paranodal myelin, nodes of Ranvier, neuromuscular junction
Disrupts cluster of sodium channels
Conduction block
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Antibodies produced cross-react with myelin, lymphocytes, and macrophages
Lymphocytic infiltration spinal roots & peripheral nerves
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B-cells create antibodies on the antigens of the
C. jejuni
Chief Complaints: Nausea, fever, watery diarrhea