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Cancer, definition is, how it happens, normally, abnormally, leads to,…

- - - - forms an oncogene
    - - molecular switch that promotes cell cycle
        
        inactive form bound to GDP & active form bound to GTP
        
        phosphorylation of kinases and transcription break
  - - - block the action of CDK/cyclin complexes on cell cycle progression
- - - - cell cycle proceeds without regulation
- - - - contact inhibition
        
        normal cells stop growing when they touch
    - - DNA synthesis checkpoint
      - mitosis checkpoint
      - CDK/cyclin complexes
        
        phosphorylate target proteins and can activate or inactivate
      - cell growth checkpoint
  - - - cancer cells ignore checkpoints
- - - - travel through the bloodstream
- - - - targets over-expression of Human Epidermal growth factor Receptor 2
    - - Inactivates Her2
      - Kills cancer cells
  - - - caused by translocation mutation
        
        forms Bcr/b-Abl enzyme
        
        hypermorphic kinase
    - - target protein doesn't react
        
        no chronic myeloid leukemia