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ALZHEIMER'S DISEASE - Coggle Diagram

- - - - tau-positive
        
        appear first across ventral cerebral cortex
        
        spread through rest of brain (spares visual cortex)
- - - - early loss of short-term memory
  - - - when neurons die, residual ghost tangle
        
        cholinergic neuron loss in nucleus basalis of Meynert
        
        ACh levels in hippocampus fall
        
        correlates with cortical atrophy
        
        ACh esterase (AChE) inhibitors
        
        reduce breakdown of remaining ACh
        
        transient symptomatic relief