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Coeliac disease - Coggle Diagram
Coeliac disease
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Management
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patient should be referred to a dietician with specific training in coeliac disease and the gluten-free diet
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Coeliac crisis
hypovolaemia, severe watery diarrhoea, acidosis, hypocalcaemia, and hypoalbuminaemia
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Definition
systemic autoimmune disease triggered by dietary gluten peptides found in wheat, rye, barley, and related grains
Immune activation in the small intestine leads to villous atrophy, hypertrophy of the intestinal crypts, and increased numbers of lymphocytes in the epithelium and lamina propria
Aetiology
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people with coeliac disease carry one of two major histocompatibility complex class-II molecules (human leukocyte antigen [HLA]-DQ2 or -DQ8) that are required to present gluten peptides in a manner that activates an antigen-specific T cell response
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