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Systemic Lupus Erythematosus (SLE) - Coggle Diagram
Systemic Lupus Erythematosus (SLE)
Altered Pathophysiology
environment
drugs, tobacco, infectious agents, diet, UV light
genetics
receptor signaling, tolerance regulation
hormones
abnormal estrogen metabolism, birth control pills
autoimmune
inflammatory cytokines activate autoreactive T and B cells
Clinical Manifestations
sun sensitivity, skin rashes
pain, joint swelling
arthritis
fatigue
wide symptom variety, difficult to diagnose
weight loss
oral ulcers
pleuritic chest pain, hypertension
muscle pain, weakness
Multi-System Alterations
Renal
glomerulonephritis
hypoalbuminemia, Na/H20 retention
basement membrane abnormalities
Vascular/Cardiac
vasculopathy
antiphospholipid antibodies
DVT, PE
atherosclerosis, HTN
vasculitis blood vessel inflammation
anemia of chronic disease, low RBCs
leukopenia, infections
Pericarditis, CAD
Pulmonary
pleuritis, pneumonitis
pulmonary HTN
SOB
Neurologic
peripheral neuropathy
confusion
psychosis
seizures
Ophthalmologic
keratoconjunctivitis sicca
Treatment
no cure
corticosteroids
immunosuppresants
hydroxychloroquine
monoclonal antibodies
GOAL: symptom remission, reduce organ damage
lifestyle modifications
Risk Factors
15-44 y/o women childbearing age
familial predisposition prior autoimmune disease
minority racial, ethnic groups
Prevention
avoid sun exposure, protective clothing,sunscreen
low impact exercise joint pain
smoking cessation
vaccinations
nutrition
Diagnostic Testing
erythrocyte sedimentation rate
kidney and liver function
biopsy
CBC
urinalysis
antinuclear antibody (ANA) test