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Dietary iron - Coggle Diagram
Dietary iron
heme iron
absorbed via carrier protein on enterocytes
stored as ferritin in enterocyte
iron exits enterocyte by ferroportin (FPN)
transported in blood bound by transferrin
hepcidin binds ferroportin to reduce iron release from enterocytes, hepatocytes and macrophages
increases in iron overload, decreases in iron deficiency
secondary iron overload disorders
chronic anaemia
(thalassemia, haemolysis, aplasia)
anaemia and hypoxia
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will not tolerate venesection
chronic liver disease
(HCV, ETOH, NASH)
inflammation of liver
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synthesised in liver
Hamp
gene
mediators of hepcidin release: transferrin receptor 2, HFE, hemojuvelin
Hereditary haemochromatosis
Primary HH (type I: HFE-related)
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HH type 2/juvenile haemochromatosis
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HH type 3/TFR2 haemochromatosis
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HH type 4/ferroportin haemochromatosis
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non-heme iron
reduced from ferric to ferrous at duodenal brush border by cytochrome B (Dcytb)
transported into enterocyte by DMT1 (divalent metal transporter)