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HEMATOIMMUNOLOGY SYSTEM, image, image, Bone Marrow, Give red color and…
HEMATOIMMUNOLOGY SYSTEM
HEMATOLOGY
BLOOD FUNCTIONS
transport of oxygen and nutrients
regulating body temperature
forming blood clots to prevent excess blood loss
BLOOD COMPONENTS
Blood Cells
(45%)
Red Blood Cells (Erythrocytes)
Hemoglobin
RBC Disorder
:
Thalassemia
Classification
Molekul
α
6 more items...
β
3 more items...
Klinis
Minor
Mayor
Prevention
: premarital screening and education
Clinical Manifestasion
Anorexia
Pale
Recurrent infection
Hepatosplenomegaly
Growth and development disturbances
Fatigue
Diagnosis
Physical Examination
Fatigue
Hepatosplenomegaly
Pale
Icterus can be found
Supporting Examination
Peripheral Blood Smear
Bone Marrow
PK
History Taking
Pale
Abdominal Enlargement
Fatigue
Family History
Management
Medikamentosa
chelating agent (desferoxamine)
Asam folat
Vitamin E
Suportif
blood transfusion
Etiology
: mutations or deletions of the Hb genes
Pathogenesis
Pathophysiology
Epidemiology:
Alpha thalassemia is prevalent in Asian and African populations while beta-thalassemia is more prevalent in the Mediterranean population, although it is relatively common in Southeast Asia and Africa too. Prevalence in these regions may be as high as 10%.
Structure
:
Consist of 4 chains of globins (2 alpha & 2 beta) and 4 heme
Every heme consist of porphyrin and one molecule of iron
Beta chains consist of 146 amino acid
Alpha chains consist of 141 amino acid
Functions
: Transporters of oxygen and nutrients to the tissues
Characteristics
Biconcave disk
No nucleus or mitocohndria
Thickness 2 micron
Diameter of 8 micron
short lifespan:
120 days
Erythropoiesis
Blood Plasma
(55%)
Plasma Proteins (7%)
Water (91%)
Bone Marrow
Give red color and maintain the shape of blood
