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Development origins of health and disease (DOHaD)- part 1 (elements that…

- - - - assumption pathological element that has slowed growth- placental insufficiency, maternal health (HTN, diabetes, asthma, smoking, sub-optimal nutrition)
      - maternal nutrition may not necessarily guarantee foetal nutrition
    - - symmetrical IUGR- if underlying cause occurs 1st or 2nd trimester.
      - Asymmetrical IUGR- problem in late preganancy. due to O2 substrate restriction late in pregnancy (last trimester). may achieve full adult growth potential still
      - Long term effects of IUGR
        
        increased risk of non-communicable health diseases
- - - - sub-study- incidence glycose tolerance and diabetes- clear inverse association between low birth weight and impaired gluocse tollerance
    - - individuals exposed to famine at preganancy (during last trimester) werre LESS likely to be obese compared to those exposed in first half which were significantly more obese
      - Those exposed early gestation had heightened risk of CVD, have increased LDL ,lower HDL
      - extreme condition (most mothers not restrcited to 400kcals) so ? generalisability
      - Lack of control / control weakness as mothers may have eaten more without reporting