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Gut microbiome Metabolites - Coggle Diagram

- - - - Bile aids play a role in weight loss after Roux-en-Y gastric bypass surgery
        After this procedure, digestive juices and food mix late in the small intestine
        Thus, limited spillover of bile acids into the colon occurs, where bile acids activate TGR5 and VDR resulting in secretion of GLP-1 and possibly FGF19
        GLP-1 will improved insulin sensitivity and secretion and FGF19 might reduce hepatic steatosis by inhibiting lipogenesis
      - Bile acids inhibit C. difficile spore germination
        SER-109 is an investigational microbiome therapeutic composed of purified Firmicutes spores for the treatment of recurrent C. difficile infection
        The percentage of patients with recurrence of C. difficile infection was 12% in the SER-109 group and 40% in the placebo group
        SER-109 dose species were associated with bile-acid profiles that are known to inhibit C. difficile spore germination