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PERIODONTAL PATHOGENESIS, Plasma cells dominate in CT - Coggle Diagram

- - - - 0-2 Days
    - - No gram negative bacteria
    - - No inflammation
      - No bleeding on probing
    - - Slight change in gum color can be normal
      - Little to no change in texture
      - https://www.sedationdentistreston.com/periodontal--gum--disease
- - - - Undertermined amount of time
        
        Host response dependent
        
        Risk factor dependent
        
        Biofilm present dependent
    - - Junctional epithelium migrates apically
      - Radiographic boneloss noted
      - Irreversible tissue damage
      - Bleeding upon probing
      - https://www.colgateprofessional.com/students-faculty/trending-topics/can-you-take-a-vacation-from-oral-care
    - - Large number of plasma cells, lymphocytes, neutrophils
        
        Neutrophils predominate in pocket epithelium
    - - Destruction of collagen fibers in PDL
      - Osteoclasts begin to resporb bone
- - - - Epithelial ridges extend deeper
      - Continued loss of collagen in CT
      - JE loosens attachemnt at root surface and transforms into pocket epithelium
      - Pocket epithelium is thinner and more permeable than GE
    - - "Plasma Cell Lesion"
      - Large number of plasma cells, B lymphocytes, neutrophils
    - - Inflamed connective tissue
        
        BOP
      - Formation of pocket epithelium
    - - 2-3 Weeks
  - - - https://www.colgateprofessional.com/students-faculty/trending-topics/can-you-take-a-vacation-from-oral-care
      - Edema
      - Redness at GM
        
        BOP
    - - More vascular permeability, vasodilation, and increased GSF
      - JE cells begin to proliferate
      - Degeneration of fibroblasts and destruction of collagen in CT
      - Collagen destruction in JE causes sulcus to get deeper
    - - Large number of infiltrating ceutrophils and T-lymphocytes
      - "T-Cell Lesion"
    - - 4-10 days after plaque develops
  - - - Tissue looks clinically healthy
      - Low-grade or no inflammation
        
        BOP likely
      - https://www.colgateprofessional.com/students-faculty/trending-topics/can-you-take-a-vacation-from-oral-care
    - - Increased vascular permeability
      - Increased GCF
      - Increased vasodilation
    - - Loss of perivascular collagen
      - Neutrophil predominant
    - - 2-4 days after plaque accumulation