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Anticancer drugs - Coggle Diagram
Anticancer drugs
Antimetabolites
Methotrexate
DHFR inhibition
Uses
Breast cancer
H&N cancer
Primary CNS lymphoma
Bladder cancer
Choriocarcinoma
Leucovorin
6-MP
Inhibits de novo purine synthesis
AML
Hepatotoxicity
5-FU
inhibits thymidylate synthase
Uses
GI cancers
HCC
H&N cancer
Neurotoxicity
Cytarabine
Gemcitabine
Pulmonary fibrosis
CCS
Misc
TKinhibitors
Imatinib
Uses
CML
GIST
Side effects
Fluid retention
ankle
Periorbital
Myalgia
Heart failure
Sorafenib
GFRinhibitors
Trastuzumab
Her2neu
Breast cancer
Cardiac dysfunction
Cetuximab
Cervical cancer
Bevacizumab
VEGF
Uses
Colorectal
Breast
nonsmall cell lung
Renal
Side effects
Arterial thromboembolism
GI perforations
Proteinuria
Wound healing complications
Rituximab
nonHodgkin lymphoma
Interferons
Hairy cell leukemia
CML
Asparaginase
Proteasome inhibitors
Bortezomib
Alkylating agents
Cyclophosphamide
Forms DNA cross links
Uses
Breast cancer
nonHodgkin lymphoma
CLL
Hemorrhagic cystitis
Mesna
Mechlorethamine
Hodgkin and nonHodgkin lymphoma
Forms blisters
Cisplatin
Side effects
Neurotoxicity
Nephrotoxicity
Carboplatin
less Neuro/Nephro toxicity
more BMS
Procarbazine
forms H2O2
free radicals
DNA strand scission
Disulfiram reaction
Leukemogenic
Used in brain tumors
CCNS
Natural anticancer
CCS
Vinca alkaloids
Block formation of mitotic spindle
M phase
Uses
Vincristine
ALL
Wilms tumor
Neuroblastoma
Vinblastine
lymphoma
Neuroblastoma
Kaposi sarcoma
Testicular carcinoma
Neurotoxicity
Vincristine
Areflexia
Peripheral neuritis
Paralytic ileus
-Posides
Topoisomerase II inhibition
GI cancers
Lung cancers
-tecans
inhibit Topoisomerase I
Ovarian carcinoma
Small cell lung carcinoma
Palcitaxel
prevent microtubule disassembly
Solid organ tumors
Side effects
-penias
HS rx
Neurotoxicity
Hormonal
Glucocorticoids
Tamoxifen
GnRH analogs
Antitumor antibiotics
Anthracyclines
act on DNA topoisomerase II
generate free radicals
Uses
Lymphoma
Meyloma
Sarcoma
Breast, lung, ovarian cancer
Dilated cardiomyopathy
Dexrazoxane
CCNS
Bleomycin
generate free radicals
CCS
Uses
Hodgkin lymphoma
Testicular
SCC
Pulmonary fibrosis