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Haematopoeitic pathology, Bone marrow, Approach, Haematopoiesis, Blood…
Haematopoeitic pathology
2 tissues
Lymphoid tissue
Accessory lymphoid tissue (MALT, tonsils)
Thymus
Spleen
Lymph nodes
Myeloid tisse
Blood cells
Mononuclear phagocyte or monocyte macrophage system
Bone marrow
Anaemia
Regenerative
Haemolytic
Post- haemorrhagic/blood-loss
Non-regenerative
Nutritional
Aplastic
Haemorrhagic diathesis
Clotting disturbances
Inherited
Acquired
Platelet disturbances
Thrombasthenia
Thrombocythaemia
Thrombocytopaenia
Vascular injury
Bone marrow
Osteomyelitis
Abnormal cell infiltration
Gelatinous/transparent marow
Neoplasia
Diffusely red marrow
Approach
Proliferative lesions
Hyperplasia
Neoplasia
hypertrophy
Inflammation
Acute
Chronic
Developmental abnormalities
Degenerative lesions
Haematopoiesis
Foetus
Thymus
Lymph nodes
Spleen
Bone marrow
Liver
Adults
Epiphysis/metaphysis of long bones
EHM- extramedullary haematopoiesis
spleen
liver
Flat bones
Scapula
Ribs
cranial bones
sternum
Neonates
Bone marrow
Lots of red marrow which will regress and become yellow marrow
Growth plate- disappears as animal grows
Embryo
stem cell clusters in yolk sac
Blood marrow
50: 50 ratio in adults
acellular adipose tissue= yellow marrow
cellular haematopoietic tissue = red bone marrow
Changes in bone marrow= cellularity
Red marrow to yellow marrow ratio
MALT-Mucosa-associated lymphoid tissue
SMALLER
LARGER