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Thymus, Bone Marrow, Spleen, Lymph Nodes, Lymphatics, MALT, Red BM 🐎 =…

- - - - Idopathic Hemorrhage
        
        Pathogenesis (Involution -> thin walled vessels no support)
        
        Dx of EXCLUSIONS
      - Traumatic Hemorrhage
      - Anticoagulant Toxicity (rodenticide)
        
        🍌 deficiency (no clotting factor replacemet)
    - - Antemortem
        
        CBC, Clotting ⏰
      - postmortem
        
        Stomach contents (🥶)
    - - Access
      - 🚗
      - Age
        
        Thymic involution @ 6-12m
  - - - 🐕
        
        Myasthenia gravis
        
        Thymoma -> autoantibodies ⚔️ thymic myoid cells (use AChR) -> Ab in circulation -> attack PS AChR at NMJ (❌ ACh binding)
      - 🐈
        
        Exfoliative dermatitis
    - - Lymphoma
    - - Thymoma
      - Thymic Carcinoma
- - - - Variation
      - Hypoplasia
      - Neoplasia
    - - Cysts
      - Neoplasia
- - - - Liver abcess
      - Pneumonia
    - - Hemolytic anemia
      - Hemorrhage
- - - - Macreophages
      - DDx - Lymphoma, Amyloidosis
    - - Dendritic Cell
      - DDx: Metastatic neoplasia, abscesses
- - - - Endothelium
      - Smooth 💪🏼 cells
      - Fibroblasts
  - - - Lymphocytes
      - Dendritic cells (Histiocytes)
    - - Adaptive immune function
  - - - Erythrocytes
      - Macrophages (histocytes)
    - - Innate immune function
      - Storage
      - EMH
- - - - Acute Septicemia
      - Barbiturates
      - Volvulus/Torsion
      - Infectious Disease
      - Acute IMHA
    - - Bacteremia/Abscess
      - Granuloma, EMH
      - Storage Material
      - Phagocytosis
      - Neoplasia
  - - - Hematoma
      - Nodular Hyperplasia
      - Neoplasia
      - Infarct
    - - Abscess/Granuloma
      - Nodular Hyperplasia
      - Infarct
      - Neoplasia
      - Siderotic Plaques
        
        Normal
- - - - Sporadic (non-BLV)
        
        Multi-centric, widlet ditributed, uterus/stomach/myocardium/CNS
      - Enzzotic (BLV)
        
        Multcentrci (<6m) - Thymic (6-24m) = ENALRGEMENT
      - Cutaneous
    - - Multicentric
      - Cutaneous
      - Ailemntary/internal
        
        GI, Regional LNs, Liver, Spleen, Peritoneum
- - - - Chronic Lymphadentitis
      - Granulomatous
      - Strangles (acute lymphanditits)
      - Caseous (CLA)
      - Follicular Hyperplasia (B-cell)
      - Abscessation
      - Metastatic Neoplasia
    - - Lymphoma 🧪
      - Diffuse Hyperplasia (T-cell)
      - Acute Lymphadentitis
- - - - Lymphocytolysis
      - Necrosis of germinal centers GALT & PPs
  - - - Tonsillitis
    - - Lymphoma
      - SCC
- - - - Paryngeal & palatine tonsils
      - PP, Bursa Fabricus
      - BALT, GALT, CALT